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Neurobiology Assay Services

Highly specialized cells need highly specialized assay services.

 

An overview of our services

The central nervous system (CNS) possesses many unique characteristics (action potentials, networking, blood brain barrier, and more) that cannot effectively be modeled with a 2D immortalized cell line such as PC-12. However, the use of more complex cell models such as primary cells is costly and can be highly variable. Thus, we offer a suite of Ready-2-Go assay services that utilize human iPSC-derived neurons and microglia to generate more relevant data for drug discovery, while minimizing variability and costs. We also have a wealth of experience in generating more complex models such as tri-cultures and 3D organoids from hiPSCs as part of our bespoke services.

Ready-2-Go Services

Ready-to-Go Assay Service

Neuronal Apoptosis & Viability

Evaluating and identifying potential neurotoxic effects of therapeutics is essential to any drug development campaign. Our R2G Neuronal Apoptosis & Viability Assay Service uses iPS-derived neuronal cells to provide you with a robust, accurate quantification of your test articles’ impact on neuronal apoptosis and viability.
Ready-to-Go Assay Service

Neurite Outgrowth & Network Dynamics

Psychiatric disorders and other diseases of the CNS are often associated with dynamic changes in the connectivity of neural networks. Typical assays measuring these dynamics use immortalized neuronal cell lines, which may not be physiologically relevant, or use costly and highly variable primary neurons. Our R2G Neurite Outgrowth and Neurite Network Dynamics assays use iPSC-derived neurons with culture conditions optimized to capture the initial outgrowth of neurites,  prior to the establishment of more mature connections, with the option to capture both in order to assess changes in steady-state network formation.
Ready-to-Go Assay Service

Neuronal Mitochondrial Health

Neurons are uniquely sensitive to disruption of mitochondrial activities due to their specialized functions (i.e. action potentials) that require high amounts of energy. These mitochondrial perturbations are thought to play a major role in many neurodegenerative diseases. Our R2G Neuronal MitoHealth Assay Service measures changes in mitochondrial function in iPSC-derived neurons to help you assess your test articles' impacts on this biological process.
Ready-to-Go Assay Service

Microglia Phagocytosis

To date, most assays developed for microglial research are conducted using immortalized and murine cell lines that do not adequately mirror human biology. Our R2G Microglia Phagocytosis Assay Service overcomes this issue by using iPSC-derived human microglia. Choose from wild-type and TREM2-mutant cells to measure your test articles' effects on phagocytosis in a fluorescent, kinetic assay.

Bespoke Assay Services

Unique Questions. Unique Solutions.