
NEUROBIOLOGY
ASSAY SERVICES
OVERVIEW
The central nervous system (CNS) possesses unique characteristics that render fruitful drug discovery and development for CNS diseases or disorders extremely challenging. Our CNS-related assay services remove much of the risk of assay failure by leveraging our scientists’ extensive expertise in working with diverse, in vitro, CNS-disease models to build and implement predictive, physiologically relevant neuronal assays. You can choose from our list of pre-validated Ready-2-Go assays, or work with our team to design a custom assay to suit your research needs.
EXAMPLES OF IN VITRO MODELS WE USE IN MONO-, CO-, OR TRI-CULTURES
- iPSC-derived neurons
- Glutaminergic, dopaminergic, GABAergic, motor, and sensory neurons
- Healthy and disease-relevant mutants
- iPSC-derived astrocytes
- iPSC-derived microglia
- Primary rat neurons
- Cell lines (e.g., PC-12, BV-2)
EXAMPLES OF ASSAYS WE DELIVER
- Cellular responses to insults (e.g., PFFs, Aβ, toxins) and therapeutic agents, such as cell viability and mitochondrial function
- Dynamic changes in neuronal morphology, such as changes in neurite outgrowth or network complexity, synapse formation, and cell-body shape and size
- Receptor/protein localization or translocation
- Cellular uptake of insults or therapeutic agents
- Synaptogenesis
- Microglial phagocytosis
EXAMPLES OF THERAPEUTIC MODALITIES WE TEST
- Small and large molecules
- Biologics
- AAV
- Lipid nanoparticles (LNP)
- Lentivirus

RELATED ASSAY SERVICES
Learn more about our assay offerings.
R2G NEUROTOXICITY
Multiplexed readouts of viability and apoptosis.
Learn more
R2G NEURONAL MITOCHONDRIAL HEALTH
Multiplexed readouts of mitochondrial health.
Learn more
R2G NEURITE OUTGROWTH & NEURITE NETWORK DYNAMICS
Quantification of neurite outgrowth and changes in established neurite networks using human, iPSC-derived neurons.
Learn more
R2G MICROGLIA PHAGOCYTOSIS
Measure uptake of a fluorescent bacterial bioparticle by human, iPSC-derived microglia.
Learn more
BESPOKE ASSAYS
Custom assays to answer more specific, complex biological questions.
Learn more
RELATED RESOURCES

TITLE
Lorem ipsum
Read more

TITLE
Lorem ipsum
Read more

TITLE
Lorem ipsum
Read more
CONTACT US
Let's discuss how we can help with your research.