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IN VITRO NEUROBIOLOGY
ASSAY SERVICES

Gain insights into your CNS-targeting drugs with our in vitro Ready-2-Go assay services, or collaborate with our team to build your customized assay.

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IN VITRO NEUROBIOLOGY
ASSAY SERVICES

Gain insights into your CNS-targeting drugs with our in vitro assay services using predictive, physiologically relevant disease models.

OUR CAPABILITIES

The central nervous system (CNS) possesses distinct qualities that make drug discovery and development for CNS diseases or disorders particularly challenging. Mitigate the risk of assay failure by leveraging our scientists' extensive expertise in working with diverse, in vitro, CNS-disease models to build and implement predictive, physiologically relevant, neuronal assays.

In Vitro Models

In Vitro Models
 Early Toxicity Motor Neuron Diseases ⓘALS, primary lateral sclerosis, progressive muscular atrophy Neurodegen. Diseases ⓘAlzheimer's, Parkinson's, multiple sclerosis
Sensory neurons
✔
✔
Glial cells
✔
✔
✔
Gluta/GABA neurons
✔
✔
Co- or tri-cultures
✔
✔
✔
Cell lines, primary cells, or iPSC-derived cells are available.

Assay Types

Assay Types Early Toxicity Motor Neuron Diseases ⓘALS, primary lateral sclerosis, progressive muscular atrophy Neurodegen. Diseases ⓘAlzheimer's, Parkinson's, multiple sclerosis
Cellular responses to insults & therapeutic agents
✔
✔
✔
Dynamic changes in neuronal morphology
✔
✔
✔
Receptor/protein localization or translocation
✔
✔
Cellular uptake of insults or therapeutic agents
✔
✔
Synaptogenesis
✔
✔
Microglial phagocytosis
✔
✔
✔

Therapeutic Modalities

Examples of therapeutic modalities we test:

  • Small molecules
  • Large molecules
  • AAV
  • Lipid nanoparticles (LNP)
  • Lentivirus

In Vitro Models

In Vitro Models Preclinical Toxicity Motor Neuron Diseases Neurodegen. Diseases
Sensory neurons ✔ ✔  
Glial cells ✔ ✔ ✔
Gluta/GABA neurons ✔   ✔
Co- or tri-cultures ✔ ✔ ✔

Cell lines, primary cells, or iPSC-derived cells are available.

Assay Types

Assay Types Preclinical Toxicity Motor Neuron Diseases Neurodegen. Diseases
Cellular responses to insults & therapeutic agents ✔ ✔ ✔
Dynamic changes in neuronal morphology ✔ ✔ ✔
Receptor/protein localization or translocation   ✔ ✔
Cellular uptake of insults or therapeutic agents   ✔ ✔
Synaptogenesis   ✔ ✔
Microglial phagocytosis ✔ ✔ ✔

Therapeutic Modalities

Examples of therapeutic modalities we test:

  • Small and large molecules
  • Biologics
  • AAV
  • Lipid nanoparticles (LNP)
  • Lentivirus

OUR CAPABILITIES

The central nervous system (CNS) possess distinct qualities that make drug discovery and development for CNS diseases or disorders particularly challenging. Mitigate the risk of failure by leveraging our scientists' extensive expertise in working with diverse, in vitro, CNS-disease models and implement predictive, physiologically relevant, neuronal assays.

Examples of in vitro models we use in mono- or multi-cultures:

  • iPSC-derived neurons (e.g., glutaminergic, dopaminergic, GABAnergic, motor, sensory)
  • Healthy and disease-relevant mutants
  • iPSC-derived astrocytes
  • iPSC-derived microglia
  • Primary rat neurons
  • Cell lines (e.g., PC-12, BV-2)

Examples of assays we deliver:

  • Cellular responses to insults (e.g., PFFs, Aβ, toxins) and therapeutic agents, such as cell viability and mitochondrial function
  • Dynamic changes in neuronal morphology, such as changes in neurite outgrowth or network complexity, synapse formation, and cell-body shape and size
  • Receptor/protein localization or translocation
  • Cellular uptake of insults or therapeutic agents
  • Synaptogenesis
  • Microglial phagocytosis

Examples of therapeutic modalities we test:

  • Small and large molecules
  • Biologics
  • AAV
  • Lipid nanoparticles (LNP)
  • Lentivirus

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APPLICATION NOTE

Alzheimer's Capabilities

Browse examples of assays we have developed in the AD space.

OUR SERVICE OFFERINGS

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CUSTOM SERVICES

Collaborate with our team to design and execute an assay based on your specialized, complex, biological questions.
Learn more

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READY-2-GO SERVICES

Choose from pre-defined assay offerings that span a range of diseases and therapeutic areas.
Learn more

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CUSTOM SERVICES

Collaborate with our team to design and execute an assay based on your specialized, complex, biological questions.
Learn more

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READY-2-GO SERVICES

Choose from pre-defined assay offerings that span a range of diseases and therapeutic areas. 
Learn more

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IMAGING & ANALYSIS

Send us plates with cells that have been fixed & stained, and we'll send you data.
Learn more

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CONSULTATION

Let our team guide you through actionable steps based on your studies' scope and goals.
Learn more

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IMAGING & ANALYSIS

Send us plates with cells that have been fixed & stained, and we'll send you data.
Learn more

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SCREENING

Identify promising compounds with high-throughput screening and analysis services.
Learn more

NEUROBIOLOGY READY-2-GO SERVICES

Choose from a list of predefined, in vitro assay offerings designed to deliver high-quality data, fast.

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R2G NEUROTOXICITY

Multiplexed readouts of viability and apoptosis.
Learn more

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R2G NEURONAL MITOCHONDRIAL HEALTH

Multiplexed readouts of mitochondrial health.
Learn more

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R2G NEURITE OUTGROWTH

Quantification of neurite outgrowth using human, iPSC-derived neurons.

Learn more

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R2G NEURITE NETWORK DYNAMICS

Quantification of changes in established neurite networks using human, iPSC-derived neurons.
Learn more

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R2G MICROGLIA PHAGOCYTOSIS

Measure uptake of a fluorescent bacterial bioparticle by human, iPSC-derived microglia.
Learn more

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R2G AAV GENE DELIVERY

Assess AAV transduction in various cell types.
Learn more

RESOURCES

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APP NOTE

Phenotypic Studies to De-risk Alzheimer's Disease R&D

Learn more about Alzheimer's disease (AD) and review examples of phenotypic studies designed to measure diverse aspects of AD-relevant biology.

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APP NOTE

Phenotypic Studies to De-risk Parkinson's Disease R&D

Learn about Parkinson's disease (PD) and review examples of phenotypic studies designed to measure aspects of PD-relevant biology.

A549 cells stained for nuclei (blue), autophagosomes (red), and autolysosomes (green).

BLOG POST | 6 MIN READ

Understanding Lysosome Dysfunction in Neurodegenerative Diseases

Learn how lysosome dysfunction impacts neurodegenerative diseases and the potential implications for future treatments.

Human, iPSC-derived cardiomyocytes transduced with AAV carrying a GFP gene.

BLOG POST | 6 MIN READ

AAVs in Gene Therapy

Learn more about the significance of AAVs as gene-therapy vectors and practical considerations for their use.

alzheimers-assay-capabilities-1200x627

APPLICATION NOTE

Alzheimer's Capabilities

Browse examples of assays we have developed in the AD space.

DISCOVER MORE WITH A PARTNER YOU CAN TRUST

"The team at PhenoVista took on a challenging project that required the development and execution of unprecedented, complex assays using healthy and mutant human, iPSC-derived neurons. To get a comprehensive understanding of the system’s biology, PhenoVista can combine several custom palettes for multiplexed imaging, or use their expertise in cell painting to get information through an un-targeted, unbiased approach. They worked with our scientists in a highly collaborative and positive manner and delivered high-quality, useful data that were well interpreted. We would happily work with them again!"

Dr. Julie Selkirk, Associate Director of Biology | Receptos

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CONTACT US

Let's discuss how we can help with your study.

CONTACT US

OVERCOME THE COMPLEXITIES OF
CNS-RELATED DRUG DISCOVERY

The central nervous system (CNS) possesses distinct qualities that make drug discovery and development for CNS diseases or disorders particularly challenging. Our CNS assay services mitigate the risk of assay failure by leveraging our scientists' extensive expertise in working with diverse, in vitro, CNS-disease models to build and implement predictive, physiologically relevant, neuronal assays.

READY-2-GO ASSAY SERVICES

Choose from a list of predefined, in vitro assay offerings designed to deliver high-quality data, fast.

neurotoxicity-icon

R2G NEUROTOXICITY

Multiplexed readouts of viability and apoptosis.
Learn more

neuronal-mitochondrial-health-icon

R2G NEURONAL MITOCHONDRIAL HEALTH

Multiplexed readouts of mitochondrial health.
Learn more

neuronal-outgrowth-icon-v2

R2G NEURITE OUTGROWTH

Quantification of neurite outgrowth using human, iPSC-derived neurons.

Learn more

neurite-network-icon-v2

R2G NEURITE NETWORK DYNAMICS

Quantification of changes in established neurite networks using human, iPSC-derived neurons.
Learn more

microglia-phagocytosis-icon

R2G MICROGLIA PHAGOCYTOSIS

Measure uptake of a fluorescent bacterial bioparticle by human, iPSC-derived microglia.
Learn more

aav-gene-delivery-icon

R2G AAV GENE DELIVERY

Assess AAV transduction in various cell types.
Learn more

APPLICABLE DISEASES

Preclinical Toxicity Depression Schizophrenia ALS Multiple Sclerosis Neurodegen.
(AD, PD, MS)		 Neuro-development
R2G Neurotoxicity ✔ ✔ ✔ ✔ ✔
R2G Neuronal Mito. Health ✔ ✔ ✔ ✔ ✔ ✔ ✔
R2G Neurite Outgrowth ✔ ✔
R2G Neurite Network Dynamics ✔ ✔ ✔ ✔ ✔
R2G Microglia Phagocytosis ✔ ✔ ✔ ✔ ✔ ✔
R2G AAV Gene Delivery ✔ ✔ ✔ ✔ ✔ ✔
cp-lines-section-break

BUILD YOUR OWN CUSTOM ASSAY

Can't find what you need? Collaborate with our team to design a custom assay suited to your research needs.

Examples of in vitro models we use in mono- or multi-cultures:

  • iPSC-derived neurons (e.g., glutaminergic, dopaminergic, GABAnergic, motor, sensory)
  • Healthy and disease-relevant mutants
  • iPSC-derived astrocytes
  • iPSC-derived microglia
  • Primary rat neurons
  • Cell lines (e.g., PC-12, BV-2)

summer2022-18

 

Examples of assays we deliver:

  • Cellular responses to insults (e.g., PFFs, Aβ, toxins) and therapeutic agents, such as cell viability and mitochondrial function
  • Dynamic changes in neuronal morphology, such as changes in neurite outgrowth or network complexity, synapse formation, and cell-body shape and size
  • Receptor/protein localization or translocation
  • Cellular uptake of insults or therapeutic agents
  • Synaptogenesis
  • Microglial phagocytosis

GABAneurons_TAU_2

 

Examples of therapeutic modalities we test:

  • Small and large molecules
  • Biologics
  • AAV
  • Lipid nanoparticles (LNP)
  • Lentivirus

L16_60x_2-bright

 

Neuronal-low

CONTACT US

Let's discuss how we can help with your research.