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NEUROBIOLOGY
ASSAY SERVICES

OVERVIEW

The central nervous system (CNS) possesses unique characteristics that render fruitful drug discovery and development for CNS diseases or disorders extremely challenging. Our CNS-related assay services remove much of the risk of assay failure by leveraging our scientists’ extensive expertise in working with diverse, in vitro, CNS-disease models to build and implement predictive, physiologically relevant neuronal assays. You can choose from our list of pre-validated Ready-2-Go assays, or work with our team to design a custom assay to suit your research needs. 

EXAMPLES OF IN VITRO MODELS WE USE IN MONO-, CO-, OR TRI-CULTURES


  • iPSC-derived neurons
  • Glutaminergic, dopaminergic, GABAergic, motor, and sensory neurons
  • Healthy and disease-relevant mutants 
  • iPSC-derived astrocytes
  • iPSC-derived microglia
  • Primary rat neurons
  • Cell lines (e.g., PC-12, BV-2)

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EXAMPLES OF ASSAYS WE DELIVER


  • Cellular responses to insults (e.g., PFFs, Aβ, toxins) and therapeutic agents, such as cell viability and mitochondrial function
  • Dynamic changes in neuronal morphology, such as changes in neurite outgrowth or network complexity, synapse formation, and cell-body shape and size
  • Receptor/protein localization or translocation
  • Cellular uptake of insults or therapeutic agents
  • Synaptogenesis
  • Microglial phagocytosis

EXAMPLES OF THERAPEUTIC MODALITIES WE TEST


  • Small and large molecules
  • Biologics
  • AAV
  • Lipid nanoparticles (LNP)
  • Lentivirus

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RELATED ASSAY SERVICES

Learn more about our assay offerings.

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R2G NEUROTOXICITY

Multiplexed readouts of viability and apoptosis.
Learn more

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R2G NEURONAL MITOCHONDRIAL HEALTH

Multiplexed readouts of mitochondrial health.
Learn more

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R2G NEURITE OUTGROWTH & NEURITE NETWORK DYNAMICS

Quantification of neurite outgrowth and changes in established neurite networks using human, iPSC-derived neurons.
Learn more

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R2G MICROGLIA PHAGOCYTOSIS

Measure uptake of a fluorescent bacterial bioparticle by human, iPSC-derived microglia.
Learn more

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BESPOKE ASSAYS

Custom assays to answer more specific, complex biological questions.
Learn more

RELATED RESOURCES

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CONTACT US

Let's discuss how we can help with your research.