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IN VITRO NEUROBIOLOGY
ASSAY SERVICES

Gain insights into your CNS-targeting drugs with our in vitro Ready-2-Go assay services, or collaborate with our team to build your customized assay.

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OVERCOME THE COMPLEXITIES OF
CNS-RELATED DRUG DISCOVERY

The central nervous system (CNS) possesses distinct qualities that make drug discovery and development for CNS diseases or disorders particularly challenging. Our CNS assay services mitigate the risk of assay failure by leveraging our scientists' extensive expertise in working with diverse, in vitro, CNS-disease models to build and implement predictive, physiologically relevant, neuronal assays.

READY-2-GO ASSAY SERVICES

Choose from a list of predefined, in vitro assay offerings designed to deliver high-quality data, fast.

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R2G NEUROTOXICITY

Multiplexed readouts of viability and apoptosis.
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R2G NEURONAL MITOCHONDRIAL HEALTH

Multiplexed readouts of mitochondrial health.
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R2G NEURITE OUTGROWTH

Quantification of neurite outgrowth using human, iPSC-derived neurons.
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R2G NEURITE NETWORK DYNAMICS

Quantification of changes in established neurite networks using human, iPSC-derived neurons.
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R2G MICROGLIA PHAGOCYTOSIS

Measure uptake of a fluorescent bacterial bioparticle by human, iPSC-derived microglia.
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NEW! R2G AAV GENE DELIVERY

Assess AAV transduction in various cell types.
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APPLICABLE DISEASES

Preclinical Toxicity Depression Schizophrenia ALS Multiple Sclerosis Neurodegen.
(AD, PD, MS)		 Neuro-development
R2G Neurotoxicity ✔ ✔ ✔ ✔ ✔
R2G Neuronal Mito. Health ✔ ✔ ✔ ✔ ✔ ✔ ✔
R2G Neurite Outgrowth ✔ ✔
R2G Neurite Network Dynamics ✔ ✔ ✔ ✔ ✔
R2G Microglia Phagocytosis ✔ ✔ ✔ ✔ ✔ ✔
R2G AAV Gene Delivery ✔ ✔ ✔ ✔ ✔ ✔
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BUILD YOUR OWN CUSTOM ASSAY

Can't find what you need? Collaborate with our team to design a custom assay suited to your research needs.

  • In vitro models
  • Assay Types
  • Therapeutic Modalities

Examples of in vitro models we use in mono- or multi-cultures:

  • iPSC-derived neurons (e.g., glutaminergic, dopaminergic, GABAnergic, motor, sensory)
  • Healthy and disease-relevant mutants
  • iPSC-derived astrocytes
  • iPSC-derived microglia
  • Primary rat neurons
  • Cell lines (e.g., PC-12, BV-2)

summer2022-18

 

Examples of assays we deliver:

  • Cellular responses to insults (e.g., PFFs, Aβ, toxins) and therapeutic agents, such as cell viability and mitochondrial function
  • Dynamic changes in neuronal morphology, such as changes in neurite outgrowth or network complexity, synapse formation, and cell-body shape and size
  • Receptor/protein localization or translocation
  • Cellular uptake of insults or therapeutic agents
  • Synaptogenesis
  • Microglial phagocytosis

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Examples of therapeutic modalities we test:

  • Small and large molecules
  • Biologics
  • AAV
  • Lipid nanoparticles (LNP)
  • Lentivirus

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EXAMPLES OF IN VITRO MODELS WE USE IN MONO-, CO-, OR TRI-CULTURES


  • iPSC-derived neurons
  • Glutaminergic, dopaminergic, GABAergic, motor, and sensory neurons
  • Healthy and disease-relevant mutants 
  • iPSC-derived astrocytes
  • iPSC-derived microglia
  • Primary rat neurons
  • Cell lines (e.g., PC-12, BV-2)

summer2022-18

 

GABAneurons_TAU_2

 

EXAMPLES OF ASSAYS WE DELIVER


  • Cellular responses to insults (e.g., PFFs, Aβ, toxins) and therapeutic agents, such as cell viability and mitochondrial function
  • Dynamic changes in neuronal morphology, such as changes in neurite outgrowth or network complexity, synapse formation, and cell-body shape and size
  • Receptor/protein localization or translocation
  • Cellular uptake of insults or therapeutic agents
  • Synaptogenesis
  • Microglial phagocytosis

EXAMPLES OF THERAPEUTIC MODALITIES WE TEST


  • Small and large molecules
  • Biologics
  • AAV
  • Lipid nanoparticles (LNP)
  • Lentivirus

L16_60x_2-bright

 

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DISCOVER MORE WITH A PARTNER YOU CAN TRUST

"The team at PhenoVista took on a challenging project that required the development and execution of unprecedented, complex assays using healthy and mutant human, iPSC-derived neurons. To get a comprehensive understanding of the system’s biology, PhenoVista can combine several custom palettes for multiplexed imaging, or use their expertise in cell painting to get information through an un-targeted, unbiased approach. They worked with our scientists in a highly collaborative and positive manner and delivered high-quality, useful data that were well interpreted. We would happily work with them again!"

Dr. Julie Selkirk, Associate Director of Biology | Receptos

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Let's discuss how we can help with your research.