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APPLICATION NOTE

Phenotypic Studies to De-risk Parkinson's Disease R&D

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APPLICATION NOTE

Phenotypic Studies to De-risk Parkinson's Disease R&D

Learn more about Parkinson's disease (PD) and review examples of phenotypic studies designed to measure various aspects of PD-relevant biology.

OVERVIEW

While incidence of Parkinson’s disease (PD) is rising, the availability of effective and novel treatments is not. Dopamine-replacement therapy has been the standard treatment for PD motor symptoms since the 1960s, even though there have been significant R&D efforts put towards gaining better understanding of PD etiology and pathology.

To aid in our clients’ R&D programs, we specialize in developing in vitro, phenotypic screening assays that range from simple, monocultures to complex, multi-cell type models. We collaborate with our clients to design custom assays that will answer their most pressing questions.

HIGHLIGHTS

We outline a few PD-relevant assays that can help your go/no-go, R&D decisions, including studies that

  • Characterize the neurotoxicity of a drug candidate
  • Characterize the effect of a drug candidate on mitochondrial stress and dopamine production
  • Characterize the effect of a drug candidate on lysosome function

REPRESENTATIVE IMAGES

Representative images of neurons treated with vehicle, glutamate, or staurosporine and stained for nuclei (Hoechst), apoptosis (CellEvent), or death (DRAQ7).

parkinsons-neurotoxicity-rep-images

REPRESENTATIVE IMAGES

Representative images of neurons treated with vehicle, glutamate, or staurosporine and stained with nuclei (Hoechst), apoptosis (CellEvent), or death (DRAQ7).

parkinsons-neurotoxicity-rep-images

DOWNLOAD THE COMPLETE APP NOTE

  • Explore three example studies characterizing the effect of drug candidates on neurotoxicity, mitochondrial stress and dopamine production, and lysosome function
  • Browse representative images and data
parkinsons-capabilities-thumbnail

DOWNLOAD THE COMPLETE APP NOTE

  • Explore three example studies characterizing the effect of drug candidates on neurotoxicity, mitochondrial stress and dopamine production, and lysosome function
  • Browse representative images and data

 

parkinsons-capabilities-thumbnail

 

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CASE STUDY

Evaluating a Therapeutic Candidate's Protective Efficacy in ALS-relevant, Motor-neuron Co-culture Models

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CASE STUDY

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CONTACT US

Let's discuss how we can help with your next study.

DOWNLOAD THE APPLICATION NOTE

Phenotypic Studies to De-risk Parkinson's Disease R&D

Overview

Learn more about Parkinson's disease (PD) and review examples of phenotypic studies designed to measure diverse aspects of PD-relevant biology.

Highlights

  • Three example studies characterizing the effect of drug candidates on neurotoxicity, mitochondrial stress and dopamine production, and lysosome function
  • Representative images and data

 

parkinsons-capabilities-thumbnail