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CELL PAINTING
SERVICES

An untargeted, unbiased, whole-cell assessment of compounds' effects on cellular phenotypes.
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WHAT IS CELL PAINTING?

Cell Painting is an unbiased, image-based, phenotypic profiling method that is revolutionizing the drug-discovery process in the biotech and pharmaceutical industries. Cells are stained with a palette of fluorescent dyes to identify and measure phenotypic differences, mechanisms of action, and early toxicology by comparing their phenotypic profiles with reference compounds and/or libraries.

Cell Painting requires a significant financial investment in order to support the needed equipment and personnel with the expertise to execute these assays. Our Cell Painting Assay Service provides customers who are interested in exploring this game-changing methodology, but who may not be ready to fully invest, a more gradual approach to evaluating the technology.

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ADVANTAGES OF CELL PAINTING 

  • Assess phenotypic differences between healthy and disease models.
  • Use treatments to detect early signs of off-target effects.
  • Available both as a pre-configured or fully bespoke assay.
  • High sensitivity of the assay allows for the detection of distinct differences in cell phenotypes while still capturing whole-cell formation.
  • Sophisticated, large datasets are ideal for machine learning and AI data approaches.
ORGANELLE OR STRUCTURE DYES
Nucleus Hoechst
Endoplasmic Reticulum Concanavalin A (Alexa Fluor 488)
Nucleoli & Cytoplasmic RNA SYTO 14
Golgi & Plasma Membrane Wheat germ agglutinin (Alexa Fluor 555)
F-actin Phalloidin (Alexa Fluor 568)
Mitochondria MitoTracker Deep Red FM

TESTIMONIAL HERE

APPLICATIONS OF CELL PAINTING IN DRUG DISCOVERY

Quality Control

The technique is highly sensitive to changes in phenotypes, making it useful for detecting assay instability.

Mechanism of Action (MOA)

Image profiles generated by Cell Painting are clustered by similarities in phenotypic readouts. The close clustering of a novel compound with unknown MOA to that with compounds of a known MOA suggest that they share a common or similar MOA.

Assay Development

Cell Painting can be used to discover phenotypic differences between disease and healthy cell models. If differences are found, then it can potentially be used as the readout in a screening campaign.

BLOG POST | 3 MIN READ

Cell Painting in Preclinical Safety and Toxicology: Literally Taking a Closer Look

Cell Painting offers immense potential for the future of drug discovery. Learn more about this powerful, imaging-based technique and how it can enhance preclinical safety and toxicology assessments of therapeutic candidates.

Start Reading
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CELL PAINTING TECHNIQUE

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ORGANELLE OR STRUCTURE DYES
Nucleus Hoechst
Endoplasmic Reticulum Concanavalin A (Alexa Fluor 488)
Nucleoli & Cytoplasmic RNA SYTO 14
Golgi & Plasma Membrane Wheat germ agglutinin (Alexa Fluor 555)
F-actin Phalloidin (Alexa Fluor 568)
Mitochondria MitoTracker Deep Red FM
Primary normal human lung fibroblasts stained with Hoechst, alpha-SMA, phalloidin/F-actin, and alpha-SMA/F-actin overlap.
Primary normal human lung fibroblasts stained with Hoechst, alpha-SMA, phalloidin/F-actin, and alpha-SMA/F-actin overlap.

FEATURE EXTRACTION & CLUSTERING

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