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IN VITRO FIBROSIS
ASSAY SERVICES

Gain insights into your anti-fibrotic drug candidates with our in vitro, Ready-2-Go assay services, or collaborate with our team to build a customized assay.

OUR CAPABILITIES

The history of failure of anti-fibrotic agents at clinical stages highlights the need for robust, scalable, physiologically relevant assays to maximize the potential of clinical success. Our in vitro assays model various types of fibrosis with cell-culture protocols that minimize basal fibrotic activation to offer quick, reproducible data in a predictable assay window, so you can avoid the cost- and time-prohibitive barriers that are inherent to animal models.

In Vitro Models

In Vitro Models

 Oncology Pulmonary Fibrosis NASH/Liver Cirrhosis

Skin Fibrosis
Lung fibroblasts
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Hepatic stellate cells
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Dermal cells
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Cell lines, primary cells, or iPSC-derived cells are available.

Assay Types

Assay Types Oncology Pulmonary Fibrosis NASH/Liver Cirrhosis Skin Fibrosis
Fibrotic induction
 
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In vitro toxicology
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ECM deposition
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Morphological changes
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Pathway activation
 
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Therapeutic Modalities

Examples of therapeutic modalities we test:

  • Small molecules
  • Large molecules
  • AAV
  • Lipid nanoparticles (LNP)
  • Lentivirus

OUR SERVICE OFFERINGS

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CUSTOM SERVICES

Collaborate with our team to design and execute an assay based on your specialized, complex, biological questions.
Learn more

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READY-2-GO SERVICES

Choose from pre-defined assay offerings that span a range of diseases and therapeutic areas. 
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IMAGING & ANALYSIS

Send us plates with cells that have been fixed & stained, and we'll send you data.
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FIBROSIS READY-2-GO SERVICES

Choose from a list of predefined, in vitro assay offerings designed to deliver high-quality data, fast.

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R2G LUNG FIBROSIS

Fibrotic induction and inhibition are measured in lung fibroblasts.
Learn more

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R2G LIVER FIBROSIS

Fibrotic induction and inhibition are measured in stellate cells.
Learn more

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R2G CELL HEALTH

Multiplexed readouts of proliferation, viability, and apoptosis.
Learn more

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R2G MITOCHONDRIAL HEALTH

Screen for changes in mitochondrial membrane potential.
Learn more

RESOURCES

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APP NOTE

Phenotypic Studies to De-risk Fibrosis R&D

Learn more about fibrosis and review examples of phenotypic studies designed to measure diverse aspects of fibrosis-relevant biology.

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CASE STUDY

Induction & Inhibition of Fibrotic State Using a Novel, Biologic Therapeutic

Browse an example of a study designed to measure fibrosis induction and inhibition in hepatic stellate cells.

Primary normal human lung fibroblasts stained with Hoechst, alpha-SMA, phalloidin/F-actin, and alpha-SMA/F-actin overlap.

BLOG POST | 6 MIN READ

Exploring Advancements in In Vitro Fibrosis Models

Learn more about recent advancements in in vitro fibrosis models and their applications in research and drug development.

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CONTACT US

Let's discuss how we can help with your study.

CONTACT US

READY-2-GO ASSAY SERVICES

Choose from a list of predefined, in vitro assay offerings designed to deliver high-quality data, fast.

lung-fibrosis-icon

R2G LUNG FIBROSIS

Fibrotic induction and inhibition are measured in lung fibroblasts.
Learn more

liver-fibrosis-icon

R2G LIVER FIBROSIS

Fibrotic induction and inhibition are measured in stellate cells.
Learn more

cell-health-icon

R2G CELL HEALTH

Multiplexed readouts of proliferation, viability, and apoptosis.
Learn more

mitochondrial-health-icon

R2G MITOCHONDRIAL HEALTH

Screen for changes in mitochondrial membrane potential.
Learn more

aav-gene-delivery-icon

R2G AAV GENE DELIVERY

Assess AAV transduction in various cell types.
Learn more

APPLICABLE DISEASES

Preclinical Toxicity Oncology Pulmonary Fibrosis NASH/Liver Cirrhosis Neurodegen.
(AD, PD, MS)		 Psychiatric Disorders Neuro-development
R2G Lung Fibrosis ✔ ✔
R2G Liver Fibrosis ✔ ✔
R2G Cell Health ✔ ✔ ✔ ✔
R2G Mitochondrial Health ✔ ✔ ✔ ✔
R2G AAV Gene Delivery ✔ ✔ ✔ ✔ ✔ ✔
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BUILD YOUR OWN CUSTOM ASSAY

Can't find what you need? Collaborate with our team to design a custom assay suited to your research needs.

Examples of in vitro models we use in mono- or multi-cultures:

  • Primary cells (e.g., normal human lung fibroblasts, hepatic stellate cells, dermal cells)
  • Cell lines (e.g., MRC-5 )

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Examples of assays we deliver:

  • Fibrotic induction
  • Prevention or reversal of fibrotic induction
  • Off-target effects for early toxicology (e.g., cell painting)
  • Fibronectin deposition
  • Morphological changes (cell-body shape and size, stress-fiber formation)
  • Pathway activation

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Examples of therapeutic modalities we test:

  • Small and large molecules
  • Biologics
  • AAV
  • Lipid nanoparticles (LNP)
  • Lentivirus

NHLFs5

 

Normal Human Lung Fibroblasts (NHLF) stained with Hoechst, Phalloidin, and MitoTracker.
BLOG POST | 7 MIN READ

Exploring Advancements in In Vitro Fibrosis Models

Learn more about recent advancements in in vitro fibrosis models and their applications in research and drug development.

START READING
Primary normal human lung fibroblasts stained with Hoechst, alpha-SMA, phalloidin/F-actin, and alpha-SMA/F-actin overlap.

CONTACT US

Let's discuss how we can help with your research.