IN VITRO FIBROSIS
Gain insights into your anti-fibrotic drug candidates with our in vitro, Ready-2-Go assay services, or collaborate with our team to build your customized assay.
MAXIMIZE CLINICAL SUCCESS OF ANTI-FIBROTIC TREATMENTS
The history of failure of anti-fibrotic agents at clinical stages highlights the need for robust, scalable, physiologically relevant assays to maximize the potential of clinical success. Our in vitro assays model various types of fibrosis with cell-culture protocols that minimize basal fibrotic activation to offer quick, reproducible data in a predictable assay window, so you can avoid the cost- and time-prohibitive barriers that are inherent to animal models.
READY-2-GO ASSAY SERVICES
Choose from a list of predefined, in vitro assay offerings designed to deliver high-quality data, fast.
R2G LUNG FIBROSIS
Fibrotic induction and inhibition are measured in lung fibroblasts.
R2G LIVER FIBROSIS
Fibrotic induction and inhibition are measured in stellate cells.
R2G CELL HEALTH
Multiplexed readouts of proliferation, viability, and apoptosis.
R2G MITOCHONDRIAL HEALTH
Screen for changes in mitochondrial membrane potential.
R2G AAV GENE DELIVERY
Assess AAV transduction in various cell types.
BUILD YOUR OWN CUSTOM ASSAY
Can't find what you need? Collaborate with our team to design a custom assay suited to your research needs.
- In vitro models
- Assay Types
- Therapeutic Modalities
Examples of in vitro models we use in mono- or multi-cultures:
- Primary cells (e.g., normal human lung fibroblasts, hepatic stellate cells, dermal cells)
- Cell lines (e.g., MRC-5 )
Examples of assays we deliver:
- Fibrotic induction
- Prevention or reversal of fibrotic induction
- Off-target effects for early toxicology (e.g., cell painting)
- Fibronectin deposition
- Morphological changes (cell-body shape and size, stress-fiber formation)
- Pathway activation
Examples of therapeutic modalities we test:
- Small and large molecules
- Lipid nanoparticles (LNP)
Exploring Advancements in In Vitro Fibrosis Models
Learn more about recent advancements in in vitro fibrosis models and their applications in research and drug development.
Let's discuss how we can help with your research.