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APPLICATION NOTE

Phenotypic Studies to De-risk Parkinson's Disease R&D

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APPLICATION NOTE

Phenotypic Studies to De-risk Fibrosis R&D

Learn more about fibrosis and review examples of phenotypic studies designed to measure various aspects of fibrosis-relevant biology.

OVERVIEW

Thickened, stiff, damaged tissue is the hallmark of fibrosis – a potentially deadly disease that can result from a multitude of causes and affect numerous organs. Although fibrosis itself is a disease, it is also affiliated with other conditions, such as cancer and inflammatory disorders, rendering it a fulcrum point of diverse R&D studies and efforts.

To aid in our clients’ R&D programs, we specialize in developing in vitro, phenotypic screening assays that range from simple, monocultures to complex, multi-cell type models. We collaborate with our clients to design custom assays that will answer their most pressing questions.

HIGHLIGHTS

We outline a few fibrosis-relevant assays that can help your go/no-go, R&D decisions, including studies that characterize the effect of a drug candidate on: 

  • Formation of stress fibers
  • Fibrosis pathway activation
  • Deposition of extracellular-matrix proteins

REPRESENTATIVE IMAGES

Representative images of primary NHLFs stained for nuclei (Hoechst), α-SMA, and F-actin (phalloidin) 72hrs after treatment.

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REPRESENTATIVE IMAGES

Representative images of neurons treated with vehicle, glutamate, or staurosporine and stained with nuclei (Hoechst), apoptosis (CellEvent), or death (DRAQ7).

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DOWNLOAD THE COMPLETE APP NOTE

  • Explore three example studies characterizing the effect of drug candidates on the formation of stress fibers, fibrosis-pathway activation, and deposition of extracellular-matrix proteins
  • Browse representative images and data
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DOWNLOAD THE COMPLETE APP NOTE

  • Explore three example studies characterizing the effect of drug candidates on neurotoxicity, mitochondrial stress and dopamine production, and lysosome function
  • Browse representative images and data

 

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RELATED RESOURCES

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CASE STUDY

Induction & Inhibition of Fibrotic State Using a Novel, Biologic Therapeutic

Review an example of a study designed to measure fibrosis induction and inhibition in hepatic stellate cells.

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BROCHURE

Ready-2-Go Lung Fibrosis Handout

Learn more about how PhenoVista’s R2G Lung Fibrosis Assay Service can help you measure fibrotic induction and inhibition in human, primary lung fibroblasts.

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BROCHURE

Ready-2-Go Liver Fibrosis Handout

Learn more about how PhenoVista’s R2G Liver Fibrosis Assay Service can help you measure fibrotic induction and inhibition in hepatic stellate cells.

CONTACT US

Let's discuss how we can help with your next study.

DOWNLOAD THE APPLICATION NOTE

Phenotypic Studies to De-risk Parkinson's Disease R&D

Overview

Learn more about Parkinson's disease (PD) and review examples of phenotypic studies designed to measure diverse aspects of PD-relevant biology.

Highlights

  • Three example studies characterizing the effect of drug candidates on neurotoxicity, mitochondrial stress and dopamine production, and lysosome function
  • Representative images and data

 

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