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APPLICATION NOTE

Phenotypic Studies to De-risk Immuno-oncology R&D

Learn more about immuno-oncology and review examples of phenotypic studies designed to measure diverse aspects of I-O biology.

OVERVIEW

The increasing understanding of the importance and potential of the immune system in preventing or halting cancer progression has opened numerous opportunities for developing new cancer therapies. The modulation of immune-system functions to harness a patient’s own body to fight the disease has been the goal of many R&D programs in the biopharma industry.

To aid in our clients’ R&D programs, we develop in vitro screening assays that range from simple monocultures to complex, multi cell-type models. We collaborate with our clients to design custom assays that will answer their most pressing questions.

HIGHLIGHTS

We outline a few immuno-oncology assays that can help inform your go/no-go, R&D decisions, including studies that:

  • Measure the ability of a drug candidate to enhance T-cell killing of tumor spheroids
  • Characterize the ability of a drug candidate to penetrate tumor spheroids
  • Develop a 3D, bioprinted model of glioblastoma for testing therapeutic candidates

REPRESENTATIVE IMAGES

Representative images of A375 spheroids (green) co-cultured with PBMCs (red) at 48hrs in a 3D, T-cell killing assay.

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  • Explore example studies that characterize the ability of drug candidates to enhance T-cell killing and penetration of tumor spheroids and a study using a 3D, bioprinted model of glioblastoma
  • Browse representative images and quantitative data
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CONTACT US

Let's discuss how we can help with your next study.

DOWNLOAD THE APPLICATION NOTE

Phenotypic Studies to De-risk Alzheimer's Disease R&D

Overview

Learn more about Alzheimer's disease (AD) and review examples of phenotypic studies designed to measure diverse aspects of AD-relevant biology.

Highlights

  • Overview of Alzheimer's disease
  • Three example studies characterizing the effect of drug candidates on neurite networks and mitochondrial health, microglia phagocytosis, and AAV gene delivery
  • Representative images and data

 

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