EXAMPLES
ALS-Relevant Assay Capabilities
Questions We Can Help Answer
- Does my therapeutic agent protect against neurotoxicity?
- Does my therapeutic agent affect or prevent neurite-network perturbations?
- Does my therapeutic agent affect TDP-43 expression and/or location?
ASSESSMENT OF PROTECTION AGAINST NEUROTOXICITY
WT iPSC-derived motor neurons co-cultured with primary, human astrocytes
ANALYSIS OF NEURITE NETWORK
WT vs. mutant iCell motor neurons treated with hydrogen peroxide
ASSESSMENT OF MITOCHONDRIAL FUNCTION
SOD1A4V vs ALS patient-derived motor neurons treated with kainate
ANALYSIS OF TDP-43 LOCATION
WT iPSC-derived motor neurons co-cultured with primary, human astrocytes
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