
READY-2-GO
NEURITE NETWORK DYNAMICS
ASSAY SERVICE
Assess the effects of your compound on established neurite networks using human, iPSC-derived neurons.
NEURITE NETWORKS: A KEY TARGET FOR NEUROGENERATIVE DISEASES
Neuronal injury or neurogenerative diseases often feature perturbations in neurite networks, and CNS-targeting therapeutics often aim to restore/repair those networks.
Our Ready-2-Go Assay Service quantitatively assesses the effect of therapeutics on established networks of human, iPSC-derived, glutamatergic neurons to provide insights into the toxicity profiles of your therapeutic candidates.
KEY FEATURES


Quantitative, morphological measurements of neurites and soma


Option to bundle R2G Services or transition to Bespoke Services
ASSESS YOUR THERAPEUTICS' EFFECT ON NEURITE NETWORKS
Human, iPSC-derived, glutamatergic neurons are cultured for a week before treatment with reference compounds and your test articles. Images are then acquired and analyzed at various time points to assess changes in neurite-network metrics.

AVOID SPECIES DIFFERENCES WITH HUMAN, iPSC-DERIVED NEURONS
The use of animal models or immortalized cell lines limits clinical translatability. We use human, iPSC-derived glutamatergic neurons to help bridge the gap between the bench and clinic.
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R2G MICROGLIA PHAGOCYTOSIS
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R2G NEURITE OUTGROWTH
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BESPOKE ASSAY SERVICES
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