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UNDERSTAND
COMPLEX BIOLOGY,
FASTER

We develop and execute difficult in vitro assays with precision and speed. Our best-in-class team works with leading biotech and pharmaceutical companies around the world to answer their complex biological questions.

UNDERSTAND COMPLEX BIOLOGY, FASTER

We develop and execute difficult in vitro assays with precision and speed. Our best-in-class team works with leading biotech and pharmaceutical companies around the world to answer their complex biological questions.

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IN VITRO ASSAYS PLAY A KEY ROLE IN DRUG DISCOVERY

In vitro assays offer a cost-effective, efficient, and highly reliable way to screen candidate compounds in the early stages of drug development. Whether identifying promising, novel agents or aiming to enhance existing treatments, in vitro assays can be applied to a wide range of systems, from simple mono-cultures of immortalized cell lines to complex cultures of patient-derived tissue samples or iPSC-derived cells.

Benefits include:

  • Scalable to high-throughput formats
  • Ability to isolate, control, and study specific pathways or systems of interest
  • Fast turnaround time compared to in vivo assays

PHENOTYPIC STUDIES PLAY A KEY ROLE IN DRUG DISCOVERY

High-stakes decision making is at the heart of drug discovery and development. Uncertainty about targets, mechanisms of action, and whether to advance or abandon candidate compounds is the norm.

Because they provide only limited data, conventional low-plex in vitro assays don’t bring enough clarity to these complex questions.

With our expertise in the development and use of high-content imaging-based phenotypic assays, we deliver the biological insights and high-quality data you need to inform and de-risk R&D decisions.

PHENOTYPIC STUDIES PLAY A KEY ROLE IN DRUG DISCOVERY

High-stakes decision making is at the heart of drug discovery and development. Uncertainty about targets, mechanisms of action, and whether to advance or abandon candidate compounds is the norm.

Because they provide only limited data, conventional low-plex in vitro assays don’t bring enough clarity to these complex questions.

With our expertise in the development and use of high-content imaging-based phenotypic assays, we deliver the biological insights and high-quality data you need to inform and de-risk R&D decisions.

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THE DRUG DEVELOPMENT PIPELINE

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EMPOWERING MORE EFFECTIVE R&D
WITH HIGH-QUALITY DATA


High-stakes decision making is at the heart of drug discovery and development. Uncertainty about targets, mechanisms of action, and whether to advance or abandon candidate compounds is the norm. Because they provide only limited data, conventional low-plex in vitro assays don’t bring enough clarity to these complex questions. With our expertise in the development and use of high-content imaging-based phenotypic assays, we deliver the biological insights and high-quality data you need to inform and de-risk R&D decisions.

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Mechanism of Action

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Target Dynamics

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Therapeutic Efficacy

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Therapeutic Uptake

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AAV Dynamics

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Subcellular Behavior

RESOURCES

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WEBINAR

Practical Considerations for Designing & Executing High-content Screens

Learn about the basic principles and process of high-content screening with tips on how to design a successful assay.

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APPLICATION NOTE

Cell Painting App Note

This application note reviews the basics of cell painting and includes an example using human, iPSC-derived hepatocytes.

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APPLICATION NOTE

Phenotypic Studies to De-risk Alzheimer's Disease R&D

Browse examples of phenotypic assays designed to measure diverse aspects of AD-relevant biology.

HARNESS THE POTENTIAL OF HIGH-CONTENT IMAGING

Our team helps you understand complex biology, with high-content imaging as our primary technique. We excel in in vitro assay development, using cutting-edge equipment and data analysis to support your research needs.

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CLOSING THE TRANSLATIONAL GAP WITH RELEVANT CELL MODELS

Animal models do not mirror human biology. At PhenoVista, we can work with human cell models to ensure repeatable, reliable, and clinically translatable data.

OUR APPROACH

One assay does not fit all. We leverage the strengths and benefits of a variety of instruments, rather than manipulate assays and conditions to fit a specific piece of equipment. This empowers us to tackle problems from multiple perspectives.

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Imaging Platforms - PerkinElmer Operetta
- Thermo CellInsight CX7 LED
- Thermo CellInsight CX7 LZR
- Yokogawa CQ1
- GE InCell 6500HS
- Thermo Cellomics ArrayScan VTI
- ECHO Revolve Fluorescence Microscope
- Sartorius Incucyte
- Araceli Endeavor

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Automation - Apricot 384-tip liquid-handling robots
- I.DOT 384- or 1536-tip liquid handler
- Tecan D300 digital dispenser
- Opentrons OT-2 liquid handler

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Analysis & Computation - Dedicated multi-GB network and multi-TB cloud-based computing
- Machine-learning and image deconvolution
- Professionally managed IT environment with data backup and disaster recovery

EXPLORE OUR SERVICE OFFERINGS

Our expertise relies on the use of physiologically relevant cell models and high-content imaging to get you actionable insights into the effects of your therapeutic agents in various areas of disease research.

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CUSTOM ASSAYS

Custom assays to answer your specific, complex biological questions.
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READY-2-GO

Defined assay offerings across a range of disease and therapeutic areas.
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CELL PAINTING

Compare your compounds' effects against those of reference compounds.
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IMAGING & ANALYSIS

You send us plates with cells that have been fixed & stained, and we'll send you data.
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CONTACT US

Let's discuss how we can help with your research.