NEURITE OUTGROWTH: A KEY ASPECT OF NEURONAL DEVELOPMENT
Neurites, comprised of axons and dendrites, form the functional network by which neurons connect to enable signal transduction and proper development and differentiation. The ability of neurons to grow these networks determines their overall effectiveness at carrying out their functions.
Our Ready-2-Go Assay Service assesses your test articles’ effects on neuronal development in new or developing human, iPSC-derived glutamatergic neurons to provide actionable insights into the safety and toxicity of your therapeutic candidate.
Quantitative, morphological measurements of neurites and soma
Option to bundle R2G Services or transition to Bespoke Services
ASSESS YOUR THERAPEUTICS' EFFECT ON NEURITE OUTGROWTH
Human, iPSC-derived, glutamatergic neurons are treated with reference compounds and your test articles shortly after seeding. Images are then acquired and analyzed at various time points for various neurite-outgrowth metrics.
AVOID SPECIES DIFFERENCES WITH HUMAN, iPSC-DERIVED NEURONS
The use of animal models or immortalized cell lines limits clinical translatability. We use human, iPSC-glutamatergic neurons to help bridge the gap between the bench and clinic.
RELATED READY-2-GO SERVICES
Browse related Ready-2-Go assay offerings. For custom assays, check out our Bespoke Services.
Multiplexed readouts of viability and apoptosis.
R2G NEURONAL MITOCHONDRIAL HEALTH
Multiplexed readouts of mitochondrial health.
R2G MICROGLIA PHAGOCYTOSIS
Measure uptake of a fluorescent bacterial bioparticle by human, iPSC-derived human microglia.
R2G NEURITE NETWORK DYNAMICS
Quantification of changes in established neurite networks using human, iPSC-derived neurons.
Let's discuss how we can help with your research.