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READY-2-GO
MICROGLIA PHAGOCYTOSIS
ASSAY SERVICE

Measure the uptake of bacterial bioparticles by human, iPSC-derived microglia.

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 MICROGLIA: A PROMISING TARGET FOR DRUG DEVELOPMENT

Microglia are the immune-effector cells in the CNS that are activated in response to injury, neurodegeneration, and infection, with one of their major functions being phagocytosis of potential threats, such as pathogens. Identifying therapeutics that can modulate microglia activity remains a promising avenue for drug development, particularly for neurodegenerative diseases, in which prolonged activation of microglia leads to neuronal death.

Our Ready-2-Go Assay Service incorporates Alzheimer’s disease relevance by providing the option of using wild-type, TREM2-homozygous, or TREM2-heterozygous cells to assess your compounds’ effects on microglial phagocytosis.

KEY FEATURES

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Uses wild-type or TREM2-mutant, human, iPSC-derived microglia

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Quantitative, live-cell and endpoint measurements of phagocytosis

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Only 4-6 weeks from assay to report

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Option to bundle R2G Services or transition to Custom Services

ASSESS YOUR THERAPEUTICS' EFFECT ON PHAGOCYTOSIS ACTIVATION

iPSC-microglia are treated with reference compounds that promote or inhibit activation of phagocytosis alongside your test articles. Fluorescence of bacterial bioparticles is measured every hour for 24 hours.

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AVOID SPECIES DIFFERENCES WITH HUMAN, iPSC-DERIVED MICROGLIA

The use of animal models or immortalized cell lines limits clinical translatability. Choose from wild-type, TREM2-homozygous, or TREM2-heterozygous, human, iPSC-derived microglia for a scalable and clinically relevant model.

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LEARN MORE ABOUT
CUSTOM ASSAY SERVICES

Can't find what you need? Work with our team to design a custom assay.
EXPLORE CUSTOM OPTIONS