DISTINGUISHING BETWEEN DIFFERENT MEASUREMENTS OF CELL HEALTH
Cell viability and proliferation are critical pieces of information for assessing the safety and toxicity of drugs and therapeutic candidates. Depending on the disease of interest, drug-development campaigns may seek to enhance cell repopulation - such as in degenerative diseases - or inhibit it - such as in cancer. Pathways that lead to cell death are complex and can manifest as apoptosis or necrosis, which are two mechanistically and morphologically distinct processes that both contribute to the general measurement of cell viability. Evaluating the impacts of drug candidates on these metrics are required for moving therapeutic candidates into the clinic, but distinguishing between these processes can prove challenging. Furthermore, dead cells in vitro often detach from the growth surface, rendering accurate measurements of viability and proliferation with antibody-based detection difficult due to cell loss exacerbated by pipetting and wash steps.
GET MULTI-PARAMETER ASSESSMENTS OF CELL HEALTH
Our Ready-2-Go Cell Health Assay Service provides multi-parameter assessments that quantitatively measure cell proliferation, apoptosis, and viability using an antibody-free protocol that minimizes the number of pipetting actions that would exacerbate cell detachment and result in skewed data. Combining this assay with our Ready-2-Go Mitochondrial Health Assay Service provides you with a general toxicity framework of your drug candidates that can save you time and money in your drug-development campaign.
APPLICABLE RESEARCH & DISEASE AREAS
Any and all! Assessments of cell viability and proliferation are indispensable to drug safety and toxicology assessments.
RELATED READY-2-GO SERVICES
Browse related Ready-2-Go assay offerings. For custom assays, check out our Bespoke Services.
R2G MITOCHONDRIAL HEALTH
Screen for changes in mitochondrial membrane potential.
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Stress fibers are measured in NHLFs.
Multiplexed readouts of viability and apoptosis.
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