Immunology & Inflammation Assay Services
Monitor more immune cell sub-populations with multiplexed imaging.
Overview
The human immune system plays a significant role in mitigating diverse disease pathologies, including response to foreign microbial infections and malignant cell growth. That said, when dysregulated, the immune system is directly linked to progression of autoimmune and inflammatory disease states, such as rheumatoid arthritis, multiple sclerosis, and psoriasis/psoriatic arthritis.
Myriad immune cell subtypes are generally involved in progressing the immune response to pathogens or autoimmune/inflammatory disease states. These may include T cells, B cells, macrophages, dendritic cells, and their various subtypes and polarization states.
A high-content, imaging-based approach offers several advantages in the development of novel immuno-therapeutics. Specifically, the ability to multiplex readouts enhances the value of more straightforward assays that characterize activity of therapeutic agents upon response of a single immune cell type, such as T-cell proliferation. This approach also enables assessment of therapeutic activity in more complex, physiologically relevant, in vitro models, such as primary immune cell co-cultures. Employing a high-content imaging approach can deliver highly impactful, multi-parametric data from these more challenging yet more relevant assays.