The link between Mitochondrial Health and disease has been well-documented and is increasingly a focus of the drug discovery industry.
Multiplexed analyses of mitochondrial markers with others that are relevant to your research enable a higher level of insight and decision-making.
Mitochondrial health is a key indicator in a wide range of diseases including Parkinson’s, Alzheimer’s, Muscular Dystrophy and Lou Gehrig’s disease among others.
Using quantitative imaging, we are able to measure structural markers for mitochondrial integrity as well as fluorescent indicators of mitochondrial activity. Furthermore, these output features can be multiplexed with a variety of other markers relevant to your research.
All of these markers can be applied to a wide range of cell types including human epithelial cells, myocytes and iPS-derived neurons.
HeLa human epithelial cells stained with a structural marker for the outer mitochondrial envelope (green) and a functional sensor dye (red) that detects oxidative activity. Our proprietary algorithms combine structural and functional readouts into a single robust readout (bottom left panel) enabling straightforward ranking of test compounds.