Imaging-based Phenotypic Screening is a extremely powerful and flexible approach to drug discovery and pre-clinical research.
Learn how imaging-based phenotypic assays work and what kind of information you can expect from working with us.
ANALYZING SINGLE CELLS OVER TIME
Many measurements performed on fixed samples can be performed on live cells over time. Typically, this involves use of engineered cells expressing fluorescently-tagged proteins.
The advantage of live-cell imaging is that it enables monitoring of kinetics associated with the biological process of interest.
In the schematic example shown on the right, over a 30 minute period the intensity of the protein depicted in green increases. However, the rate at which the protein accumulates is different in some cells compared others.